Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development
نویسندگان
چکیده
منابع مشابه
Physicochemical characterization and drug release of thermosensitive hydrogels composed of a hyaluronic acid/pluronic f127 graft.
Pluronic F127 (PF127) is a copolymer which forms thermosensitive hydrogels. Hyaluronic acid (HA) was grafted to PF127 to form a new hydrogel matrix (HP) for delivery of cisplatin and carboplatin. The physicochemical properties and drug delivery of the graft were examined in this study. HP system (20% HP copolymer in water) exhibited a similar sol-gel transition temperature (28.3 degrees C) as P...
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OBJECTIVE The main objective of this study was to investigate thermosensitive Pluronic F-127 (PF-127) hydrogel for the modified release of a potent alcohol and opioid antagonist, naltrexone (NTX) hydrochloride, in a subcutaneous injectable dosage form. METHODS The NTX hydrogels were prepared by the cold method, and the in vitro release profiles of various formulations were evaluated at 37°C u...
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Tianjin Key Laboratory of Pulp and Pa Technology, Tianjin 300457, China. E-m 60602226; Tel: +86-22-60602226 State Key Laboratory of Tree Genetics and Chinese Academy of Forestry, Beijing 10009 Jiangsu Province Biomass Energy and Ma Industry of Forest Products, CAF, Nanjing 2 State Key Laboratory of Pulp and Paper Technology, Guangzhou 510640, China † Electronic supplementary informa 10.1039/c6r...
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ژورنال
عنوان ژورنال: Journal of Colloid and Interface Science
سال: 2020
ISSN: 0021-9797
DOI: 10.1016/j.jcis.2019.12.096